Dantrolene RYR1 — FRCA Primary MCQ
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Correct answer: C — Inhibiting calcium release from the sarcoplasmic reticulum via the ryanodine receptor
Dantrolene inhibits calcium release from the SR by acting on the RYR1 receptor. In MH a mutation causes excessive calcium release triggered by volatile agents or suxamethonium. Initial dose is 2.5 mg/kg IV repeated to 10 mg/kg.
Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care