Phase II Metabolism Conjugation — FRCA Primary MCQ

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EasyPhysiology - Gastrointestinal & HepaticPhase II Metabolism ConjugationFRCA Primary

Phase II hepatic metabolism primarily involves:

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Correct answer: E — Conjugation reactions

Phase II involves conjugation of the drug with an endogenous polar molecule: glucuronidation (most common) / sulphation / acetylation / methylation / glutathione conjugation. The resulting highly polar conjugates are readily excreted renally or in bile.

Reference: Power Kam 2018 Principles of Physiology for the Anaesthetist