Adverse Drug Reactions Type A — FRCA Primary MCQ

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EasyPharmacology - General PrinciplesAdverse Drug Reactions Type AFRCA Primary

Which type of adverse drug reaction is dose-dependent and predictable from the known pharmacology of the drug?

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Correct answer: A — Type A (augmented)

Type A (augmented) adverse drug reactions are dose-dependent and predictable from the drug's established pharmacological actions. They represent an exaggeration of the intended or known effects, such as hypotension with an antihypertensive or bleeding with an anticoagulant, and may improve with dose reduction. Type B reactions are unusual and not readily predicted from conventional pharmacology. Type C reactions are associated with cumulative or prolonged exposure, whereas Type D reactions appear after a delay. Type E reactions occur following withdrawal or cessation of treatment. Therefore, the defining combination of dose dependence and pharmacological predictability identifies option A.

Reference: Kaufman G. Adverse drug reactions: classification, susceptibility and reporting. Nursing Standard. 2016;30(50):53-63. https://pubmed.ncbi.nlm.nih.gov/27507394/