Rocuronium ED95 — FRCA Primary MCQ
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Correct answer: D — 0.3 mg/kg, the approximate dose producing 95% twitch depression
The best answer is “0.3 mg/kg, the approximate dose producing 95% twitch depression”. ED95 is the dose producing 95% depression of a single-twitch response, conventionally about 0.3 mg/kg for rocuronium. A 0.6 mg/kg routine intubating dose is therefore approximately two ED95 doses, while higher doses are used when faster onset is required. Dose selection must still account for monitoring and the clinical context.
Reference: Rocuronium bromide, UK Summary of Product Characteristics: https://www.medicines.org.uk/emc/product/8841/smpc