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Apixaban Perioperative Timing — FRCA Final MCQ

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ModeratePreoperative AssessmentApixaban Perioperative TimingFRCA Final

Apixaban 5 mg BD for AF. How long before elective TKR to stop per ESRA?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A48 hours

ESRA 2022/BSH: stop apixaban ≥48h before surgery with neuraxial. Half-life ~12h; at 48h (4 half-lives) negligible activity. No bridging for AF. Resume 24-48h post-op.

Reference: ESRA – 2022 – Neuraxial and anticoagulation; BSH – 2022