Ketamine NMDA Pain Mechanism — FRCA Final MCQ
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Correct answer: B — NMDA receptor antagonism preventing central sensitisation
Ketamine: NMDA antagonist. Blocks central sensitisation (wind-up) in spinal dorsal horn. Reduces opioid tolerance. Sub-anaesthetic infusions (0.1-0.5 mg/kg/h) for refractory neuropathic pain, CRPS, opioid-sparing.
Reference: FPM – 2023 – Ketamine for chronic pain