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Hydrocortisone Septic Shock Evidence — FRCA Final MCQ

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HardIntensive Care MedicineHydrocortisone Septic Shock EvidenceFRCA Final

Hydrocortisone 50 mg QDS in septic shock: evidence base?

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Correct answer: B — ADRENAL: no mortality benefit but reduces vasopressor duration and ICU stay

ADRENAL trial (2018): hydrocortisone 200 mg/day did not reduce 90-day mortality BUT reduced time to shock resolution, vasopressor duration, ICU stay. SSC 2021 suggests hydrocortisone for escalating vasopressor requirements.

Reference: ADRENAL – 2018; APROCCHSS – 2018; SSC – 2021