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Severe C Difficile Treatment — FRCA Final MCQ

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ModerateIntensive Care MedicineSevere C Difficile TreatmentFRCA Final

Severe C. difficile: 10 stools/day, WCC 22, rising creatinine. First-line treatment?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Oral vancomycin 500 mg QDS + IV metronidazole 500 mg TDS

Severe/fulminant CDI (WCC >15, rising creatinine, >10 stools): oral vancomycin 500 mg QDS + IV metronidazole 500 mg TDS. Non-fulminant severe: vancomycin 125 mg QDS. FMT for recurrent (≥2 recurrences).

Reference: PHE/BSH – 2023 – C. difficile management