TXA Timing CRASH-2 — FRCA Final MCQ

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EasyTrauma & Emergency AnaesthesiaTXA Timing CRASH-2FRCA Final

TXA in trauma: current evidence base?

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Correct answer: C — 1 g IV within 3 hours — later may increase mortality

CRASH-2: TXA 1g IV/10 min + 1g/8h within 3h reduces death from bleeding. After 3h: may INCREASE mortality. Give as early as possible (ideally pre-hospital). No lab confirmation needed. Time-critical intervention.

Reference: CRASH-2 – 2010; NICE – 2023 – NG39