CBF Threshold Neuronal Injury — FRCA Final MCQ
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Correct answer: B — 10 mL/100g/min
Normal CBF ~50. At ~20: EEG fails (electrical failure). At ~10: membrane ion pump failure → irreversible cell death within minutes. Penumbra (10-20) is salvageable tissue — basis for stroke thrombolysis/thrombectomy time windows.
Reference: RCOA – 2023 – Cerebral physiology and neuroprotection