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MH Dantrolene Dose Paediatric — FRCA Final MCQ

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ModeratePaediatric AnaesthesiaMH Dantrolene Dose PaediatricFRCA Final

An 8-year-old (25 kg) develops MH during sevoflurane/suxamethonium. Initial IV dantrolene dose?

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Correct answer: D2.5 mg/kg

MH: dantrolene 2.5 mg/kg IV, repeat q5-10 min until symptoms resolve (max ~10 mg/kg). Each 20 mg vial needs 60 mL sterile water. For 25 kg: initial 62.5 mg (~3 vials). Blocks ryanodine receptor Ca²⁺ release from SR.

Reference: AAGBI – 2020 – MH crisis quick reference guide