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Amiodarone Pulmonary Toxicity High FiO2 — FRCA Final MCQ

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HardGeneral AnaesthesiaAmiodarone Pulmonary Toxicity High FiO2FRCA Final

A patient on long-term amiodarone requires GA. Which complication is most at risk during high-flow oxygen?

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Correct answer: C — Pulmonary toxicity (ARDS-like syndrome)

Amiodarone pulmonary toxicity is dramatically potentiated by high FiO2 during anaesthesia, producing acute ARDS-like picture postoperatively. Free radical-mediated damage to type II pneumocytes. Use lowest FiO2 maintaining SpO2 93-96%.

Reference: RCOA – 2023 – Anaesthetic implications of concurrent drug therapy