Propofol CSHT 4 Hours — FRCA Final MCQ

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ModerateGeneral AnaesthesiaPropofol CSHT 4 HoursFRCA Final

The context-sensitive half-time of propofol after a 4-hour infusion is approximately:

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Correct answer: B — 240 minutes

Propofol CSHT increases with infusion duration: ~10 min after 1hr, ~20-40 min after 4hrs. Peripheral compartment redistribution creates a reservoir slowing plasma decline.

Reference: RCOA – 2023 – IV pharmacokinetics