Volatile Myocardial Preconditioning — FRCA Final MCQ

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HardGeneral AnaesthesiaVolatile Myocardial PreconditioningFRCA Final

A 70-year-old man develops ST elevation in V1-V4 during colectomy. Which volatile agent has the most evidence for myocardial preconditioning?

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Correct answer: B — Sevoflurane

Sevoflurane and isoflurane have the most evidence for anaesthetic preconditioning via mitochondrial KATP channels, reducing infarct size when given before ischaemia.

Reference: RCOA – 2023 – Cardiac pharmacology; De Hert SG – 2009