Blood Gas PC Clinical Implication — FRCA Final MCQ

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EasyGeneral AnaesthesiaBlood Gas PC Clinical ImplicationFRCA Final

The blood:gas partition coefficient of desflurane is 0.42. Compared to sevoflurane (0.65), this means desflurane has:

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Correct answer: C — More hepatotoxicity

Lower blood:gas PC means less dissolves in blood, alveolar concentration rises faster, giving faster onset. Offset is also faster. Desflurane (0.42) has faster onset/offset than sevoflurane (0.65).

Reference: RCOA – 2023 – Inhalational pharmacology