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NMBA Recovery Mechanism — FRCA Final MCQ

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EasyGeneral AnaesthesiaNMBA Recovery MechanismFRCA Final

The rate of recovery from a non-depolarising neuromuscular block depends primarily on:

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Correct answer: EBody temperature alone

Recovery from non-depolarising NMBAs depends on their plasma clearance: hepatic metabolism (vecuronium, rocuronium, pancuronium), Hofmann elimination (atracurium, cisatracurium), or renal excretion (contributing to pancuronium, vecuronium). The plasma concentration falls as the drug is cleared, and the drug dissociates from the NMJ receptors down its concentration gradient. Temperature affects Hofmann elimination specifically.

Reference: RCOA – 2023 – NMBA pharmacology; Peck TE – 2014 – Pharmacology