LAST Early Signs Day Case Recognition — FRCA Final MCQ
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Correct answer: E — Anxiety attack – reassure only
Metallic taste, circumoral numbness, and tinnitus are the classic early warning signs of local anaesthetic systemic toxicity (LAST) – CNS excitation from sodium channel blockade. The LA has likely entered the systemic circulation (either intravascular injection or rapid absorption from the highly vascular spermatic cord). Immediate management: STOP further LA injection, administer 100% O2, call for help, establish IV access, and prepare Intralipid 20% (1.5 mL/kg bolus). Monitor closely for progression to seizures (CNS excitation peak) and then cardiovascular collapse (arrhythmias, cardiac arrest). Early recognition at the CNS stage allows intervention before cardiovascular toxicity.
Reference: AAGBI – 2020 – Management of severe LAST; RCOA – 2023 – Local anaesthetic toxicity