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Normal Anion Gap Acidosis — FRCA Final MCQ

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ModerateIntensive Care MedicineNormal Anion Gap AcidosisFRCA Final

A patient on ICU has an arterial blood gas showing: pH 7.32, PaCO2 3.5 kPa, PaO2 11 kPa, HCO3⁻ 13 mmol/L, Na⁺ 140, K⁺ 4.5, Cl⁻ 115. The anion gap is calculated as: Na – (Cl + HCO3) = 140 – (115+13) = 12 (normal). What type of metabolic acidosis is this?

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Correct answer: AMixed respiratory and metabolic acidosis

This is a normal anion gap (hyperchloraemic) metabolic acidosis. The anion gap is 12 mmol/L (normal 8-12). Normal AG metabolic acidosis is characterised by: low pH, low HCO3⁻, elevated chloride (hyperchloraemic), and normal anion gap. Causes include: renal tubular acidosis, diarrhoea, pancreatic fistula, ureterosigmoidostomy, and excessive 0.9% saline administration (dilutional acidosis). This contrasts with high AG acidosis (MUDPILES: methanol, uraemia, DKA, propylene glycol, isoniazid/iron, lactic acidosis, ethylene glycol, salicylates).

Reference: RCOA – 2023 – Acid-base physiology; ICS – 2023 – Metabolic disorders