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N2O Absolute Contraindications — ORE Part 1 MCQ

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ModeratePharmacology & TherapeuticsN2O Absolute ContraindicationsORE Part 1

Which factor is a contraindication to nitrous oxide/oxygen inhalation sedation in a dental surgery?

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Correct answer: AFirst trimester of pregnancy

**A is correct.** First-trimester pregnancy is listed in UK dental sedation guidance as a contraindication to nitrous oxide inhalation sedation. The concern is avoidance of non-essential nitrous oxide exposure during early fetal development; elective care requiring sedation should therefore be deferred or managed by an alternative approach where appropriate. Mild dental anxiety is instead a principal indication for inhalation sedation. Age over 50 years is not a contraindication: suitability depends on medical status and assessment rather than chronological age. Having previously accepted dentistry without sedation does not determine present sedation suitability. Well-controlled mild asthma is not, by itself, a contraindication; the patient should nevertheless undergo routine pre-sedation assessment and be clinically stable on the day of treatment.

Reference: Royal College of Surgeons of England. UK National Clinical Guidelines in Paediatric Dentistry: Managing anxious children: the use of conscious sedation in paediatric dentistry, 2002, section 2.1.2 “Contra-indications”. https://www.rcseng.ac.uk/-/media/files/rcs/fds/publications/paed_sedation.pdf?la=en