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Fingolimod – First-Dose Bradycardia — SCE Neurology MCQ

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HardMultiple Sclerosis & CNS InflammationFingolimod – First-Dose BradycardiaSCE Neurology

A 74-year-old with Parkinson disease has distressing visual hallucinations. Delirium and other triggers have been excluded, specialist-led reduction of contributory Parkinson medicines has not helped, and cognition is intact. Which pharmacological option should be considered next?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: CUse lower-dose quetiapine, explaining that this indication is off label

Explanation lettering: D = shown as A · A = shown as B · E = shown as D · B = shown as E

C is correct. After causes and medication triggers are addressed, NICE says to consider quetiapine for hallucinations or delusions in Parkinson disease without cognitive impairment, using lower doses than in other indications; the use is off label. A and B may worsen motor features, and NICE specifically says not to offer olanzapine. D invents dementia. E ignores that clozapine is offered when standard treatment fails and requires a monitoring service.

Reference: NICE NG71: Parkinson disease in adults: https://www.nice.org.uk/guidance/ng71/chapter/Recommendations