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SPMS – DMT Options — SCE Neurology MCQ

Instant feedback + full explanation. One question, done properly.

HardMultiple Sclerosis & CNS InflammationSPMS – DMT OptionsSCE Neurology

A patient has pure motor CIDP with objective demyelination and progressive proximal and distal weakness. There are no sensory symptoms. Long-term diabetes makes steroid toxicity a concern. Which induction treatment is preferred by the EAN/PNS guideline for this variant?

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Reveal the answer and explanation

Correct answer: E — Intravenous immunoglobulin as preferred first-line therapy for this pure motor variant

Explanation lettering: C = shown as A · D = shown as C · E = shown as D · A = shown as E

A is correct. IVIg and corticosteroids are strong first-line options for typical CIDP, but IVIg is specifically preferred in motor CIDP because some purely motor cases can worsen with corticosteroids; diabetes adds practical toxicity. B delays effective therapy and misplaces plasma exchange, which is strongly recommended when IVIg and steroids are ineffective. C and D are not standard first-line monotherapies for this phenotype.

Reference: EAN/PNS CIDP guideline — PubMed: https://pubmed.ncbi.nlm.nih.gov/34085743/