skip to main content

MGMT – TMZ Response — SCE Neurology MCQ

Instant feedback + full explanation. One question, done properly.

ModerateNeuro-oncologyMGMT – TMZ ResponseSCE Neurology

A 55-year-old man with MGMT methylated GBM undergoes Stupp protocol. What is the significance of MGMT methylation?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — MGMT promoter methylation predicts better response to temozolomide — the silenced repair enzyme cannot counteract TMZ-induced DNA damage, increasing tumour cell death (median survival ~22 months vs ~15 months)

MGMT methylation epigenetically silences the DNA repair enzyme, making the tumour more sensitive to alkylating chemotherapy (TMZ). Major prognostic and predictive biomarker. A: Significant. C: Still grade 4. D: Predicts better response. E: No radiation resistance link.

Reference: NICE NG99; Hegi et al. NEJM 2005