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LEV Psychiatric Effects – BRV Switch — SCE Neurology MCQ

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HardEpilepsy & Seizure DisordersLEV Psychiatric Effects – BRV SwitchSCE Neurology

A 55-year-old man on levetiracetam develops irritability and aggression. No psychiatric history. Seizures well controlled. Management?

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Correct answer: CReview levetiracetam and consider dose reduction or a better-tolerated alternative

The best answer is “Review levetiracetam and consider dose reduction or a better-tolerated alternative”. NICE bases epilepsy diagnosis and treatment on seizure type, syndrome, recurrence risk, comorbidity, pregnancy potential and medicine harms; typical provoked seizures are managed by correcting the provoking cause. The alternatives “Normal personality change, after excluding important mimics, after specialist assessment”, “Depression requiring SSRI, after specialist assessment, when the phenotype supports it”, “Seizure-related, when the phenotype supports it, within the relevant UK pathway”, “Personality disorder, within the relevant UK pathway, after excluding important mimics” are clinically adjacent possibilities, but they do not match the defining chronology, localisation, physiology, investigation result or UK management sequence in this stem.

Reference: NICE NG217 epilepsy recommendations: https://www.nice.org.uk/guidance/ng217/chapter/Recommendations