A woman taking teriflunomide wishes to conceive. Plasma concentration remains above 0.02 mg/L after treatment is stopped. Which plan correctly

Question

A woman taking teriflunomide wishes to conceive. Plasma concentration remains above 0.02 mg/L after treatment is stopped. Which plan correctly achieves and confirms accelerated elimination?

Accepted Answer

Use cholestyramine or activated charcoal, then document levels below 0.02 mg/L on two tests at least 14 days apart before proceeding

Answer

Use haemodialysis until one plasma sample is below 0.2 mg/L

Answer

Give folinic acid for 11 days and proceed once liver tests normalise

Answer

Switch immediately to another disease-modifying therapy because paternal exposure is the only reproductive risk

Answer

Wait seven days after the last tablet because teriflunomide has no clinically important enterohepatic recirculation

Teriflunomide – Elimination for Pregnancy — SCE Neurology MCQ

A woman taking teriflunomide wishes to conceive. Plasma concentration remains above 0.02 mg/L after treatment is stopped. Which plan correctly achieves and confirms accelerated elimination?