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NEDA-3 – Definition — SCE Neurology MCQ

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HardMultiple Sclerosis & CNS InflammationNEDA-3 – DefinitionSCE Neurology

A patient with MS has no relapses, but over 12 months walking deteriorates and EDSS rises by 1 point; MRI shows no new T2 lesions. How should an annual review record this?

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Reveal the answer and explanation

Correct answer: B — Progression without relapse or current MRI activity

Explanation lettering: B = shown as A · D = shown as B · A = shown as C · C = shown as D

D is correct. NICE comprehensive review separately documents evidence of progression, active disease, relapses and disability. Gradual confirmed disability accumulation can represent progression even when relapse and MRI activity are absent. It is therefore not “no disease,” treatment success or pseudo-relapse, and RIS applies to people without clinical MS.

Reference: NICE NG220 multiple sclerosis recommendations: https://www.nice.org.uk/guidance/ng220/chapter/Recommendations