DLB – Core Features and 1-Year Rule — SCE Neurology MCQ

Instant feedback + full explanation. One question, done properly.

HardNeurodegenerative DiseaseDLB – Core Features and 1-Year RuleSCE Neurology

A patient with dementia with Lewy bodies develops distressing psychosis. Which prescribing hazard is particularly important?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Severe antipsychotic sensitivity, especially with potent dopamine blockade

The best answer is “Severe antipsychotic sensitivity, especially with potent dopamine blockade”. Parkinsonian syndromes are distinguished by tempo, symmetry, eye movements, falls, autonomic and cognitive features; treatment is individualised to motor and neuropsychiatric burden. The alternatives “Predictable improvement in cognition with haloperidol”, “Absence of extrapyramidal adverse effects from antipsychotics”, “Routine need for high-dose dopamine blockade”, “Protection from neuroleptic malignant syndrome, when the phenotype supports it” are clinically adjacent possibilities, but they do not match the defining chronology, localisation, physiology, investigation result or UK management sequence in this stem.

Reference: NICE NG71 Parkinson disease recommendations: https://www.nice.org.uk/guidance/ng71/chapter/Recommendations