skip to main content

T25FW – Clinical Utility in MS — SCE Neurology MCQ

Instant feedback + full explanation. One question, done properly.

EasyMultiple Sclerosis & CNS InflammationT25FW – Clinical Utility in MSSCE Neurology

A 50-year-old man with MS has an EDSS of 4.0 (limited walking but can walk >500 m without aid or rest). His neurologist performs the Timed 25-Foot Walk as part of routine monitoring. Why is this test important in MS clinical practice?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — The T25FW is a simple, validated, reproducible measure of walking speed that is sensitive to clinically meaningful change in MS — it is used for fampridine response assessment, clinical trial endpoints, and routine monitoring of ambulatory function

The Timed 25-Foot Walk (T25FW) is a core component of the MSFC (Multiple Sclerosis Functional Composite) and is the most widely used quantitative measure of walking speed in MS. It is: (1) simple to perform (patient walks 25 feet as quickly and safely as possible), (2) reproducible, (3) sensitive to change, (4) used as the primary endpoint for fampridine trials (≥20% improvement criterion), and (5) part of routine clinical monitoring. A ≥20% change in T25FW is considered clinically meaningful. A: It is used in both research and clinical practice. C: Upper limb is assessed by 9-Hole Peg Test. D: Cognition by SDMT/PASAT. E: Bladder by urodynamics.

Reference: NICE NG100 MS; NICE TA835 Fampridine; MSFC