TSC Spasms – Vigabatrin — SCE Neurology MCQ

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ModerateEpilepsy & Seizure DisordersTSC Spasms – VigabatrinSCE Neurology

TSC with drug-resistant infantile spasms. First-line AED?

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Correct answer: D — Vigabatrin — ~95% response rate in TSC-related spasms

Explanation lettering: D = shown as A · A = shown as B · E = shown as C · B = shown as D · C = shown as E

Vigabatrin: specific first-line for TSC infantile spasms. Superior to ACTH (which is first-line for non-TSC spasms). Visual field monitoring required. A/C/D/E: Not first-line.

Reference: NICE NG217; TSC Consensus (2021)