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PDD vs DLB – 1-Year Rule — SCE Neurology MCQ

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HardNeurodegenerative DiseasePDD vs DLB – 1-Year RuleSCE Neurology

A woman has a 3-year progressive fluent aphasia. Confrontation naming is severely impaired, she cannot match low-frequency spoken words to pictures, and irregular-word reading shows surface dyslexia. Repetition and grammar remain relatively preserved. Which additional feature is most concordant with the same syndrome?

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Reveal the answer and explanation

Correct answer: A — Anterior temporal-predominant atrophy with degradation of person and object knowledge

Explanation lettering: D = shown as B · B = shown as C · C = shown as D

A is correct. Impaired naming and single-word comprehension, surface dyslexia and fluent grammar identify semantic-variant PPA, which is associated with anterior temporal degeneration and multimodal semantic loss. B is logopenic PPA. C is nonfluent/agrammatic PPA. D describes posterior cortical atrophy. E describes PSP and does not account for progressive semantic degradation.

Reference: International consensus classification of primary progressive aphasia: https://pmc.ncbi.nlm.nih.gov/articles/PMC3059138/