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PD – Hospital Medication Omission — SCE Neurology MCQ

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HardMovement DisordersPD – Hospital Medication OmissionSCE Neurology

A man with advanced Parkinson disease develops an ileus during admission. After 36 hours without co-careldopa he becomes profoundly rigid and obtunded, with temperature 39.5°C and CK 5,800 IU/L. Cultures do not suggest a new septic focus. Alongside supportive care, what is the most important immediate medicines action?

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Correct answer: BRestore equivalent dopaminergic treatment through a non-oral route selected with the Parkinson team

Abrupt interruption or sudden failure of absorption of antiparkinsonian treatment can precipitate parkinsonism-hyperpyrexia syndrome. Dopaminergic treatment must be restored through a route that can be absorbed, with a Parkinson specialist and pharmacy guiding equivalent-dose conversion while hyperthermia, rhabdomyolysis, renal risk and precipitating illness are managed. Dantrolene may be considered in selected severe cases but cannot substitute for dopamine replacement. A nominal low-dose patch, bromocriptine monotherapy or waiting for bowel recovery may leave a major dopaminergic deficit untreated.

Reference: NICE NG71, Parkinson’s disease in adults, recommendations: https://www.nice.org.uk/guidance/ng71/chapter/recommendations