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Fampridine – Threshold — SCE Neurology MCQ

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HardMultiple Sclerosis & CNS InflammationFampridine – ThresholdSCE Neurology

A newly diagnosed NHS patient with MS and impaired walking asks to start fampridine after reading about a 20% timed-walk response rule. What does current NICE NG220 recommend?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — No new NHS fampridine initiation under current commissioning guidance

Explanation lettering: B = shown as A · D = shown as B · E = shown as D · A = shown as E

C is correct. NICE recognises clinical benefit for some patients but recommends not offering fampridine for mobility problems because it is not cost effective at the current list price. The exception is people already receiving it in the NHS, who may continue until clinician and patient decide otherwise. A response threshold cannot override that commissioning recommendation.

Reference: NICE NG220 multiple sclerosis recommendations: https://www.nice.org.uk/guidance/ng220/chapter/Recommendations