HLA-B*15:02 – CBZ/OXC Avoidance — SCE Neurology MCQ

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ModerateEpilepsy & Seizure DisordersHLA-B*15:02 – CBZ/OXC AvoidanceSCE Neurology

HLA-B*15:02 positive patient. Which AEDs to avoid?

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Reveal the answer and explanation

Correct answer: A — Carbamazepine and oxcarbazepine — associated with SJS/TEN

Explanation lettering: B = shown as A · D = shown as B · E = shown as C · C = shown as D · A = shown as E

HLA-B*15:02: strongly associated with CBZ-induced SJS/TEN (OR >100 in Han Chinese). OXC also carries risk. Avoid both. A/C/D/E: Not associated.

Reference: CPIC Guidelines; BNF; NICE NG217