Opicapone – Once-Daily COMT — SCE Neurology MCQ

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ModerateMovement DisordersOpicapone – Once-Daily COMTSCE Neurology

PD patient on co-careldopa adds opicapone. Advantage over entacapone?

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Correct answer: D — Once-daily COMT inhibitor with longer duration — improves adherence

Opicapone: once-daily oral at bedtime, 24-hour COMT inhibition. BIPARK trials showed non-inferiority to entacapone. A: COMT inhibitor. C: Oral. D: Increases levodopa bioavailability. E: COMT, not MAO-B.

Reference: NICE TA738; BIPARK; BNF