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Sporadic CJD — SCE Neurology MCQ

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EasyNeurodegenerative DiseaseSporadic CJDSCE Neurology

Sporadic CJD features: rapidly progressive dementia, myoclonus, cortical ribboning on DWI, periodic sharp waves on EEG, positive RT-QuIC. No family history, no iatrogenic exposure. Subtype?

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Correct answer: B — Sporadic CJD

Sporadic CJD: ~85% of all CJD. Spontaneous, no genetic/iatrogenic/dietary cause. A: No PRNP mutations. B: vCJD has different features. C: No iatrogenic exposure. E: No cannibalism.

Reference: WHO CJD Criteria