fMRI Bilateral Language — SCE Neurology MCQ
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Correct answer: D — Restart with day 1 of the 14-day titration pack rather than resuming 20 mg
Explanation lettering: C = shown as A · D = shown as B · E = shown as C · A = shown as D · B = shown as E
A is correct: four or more consecutive missed ponesimod doses require re-initiation at day 1 of the titration regimen because heart-rate effects recur; monitoring requirements are then reassessed from the patient’s cardiac risk. B bypasses titration. C is an unsafe loading strategy. D is an invented abbreviated schedule. E confuses a restart precaution with a permanent contraindication.
Reference: Ponvory initiation-pack SmPC: https://www.medicines.org.uk/emc/product/100488/smpc