MS to NMOSD Reclassification — SCE Neurology MCQ

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HardMultiple Sclerosis & CNS InflammationMS to NMOSD ReclassificationSCE Neurology

A 55-year-old woman with MS develops LETM and tests AQP4-positive. She was diagnosed with MS. What should happen?

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Correct answer: B — Reclassify to AQP4-positive NMOSD — stop MS DMTs as they may worsen NMOSD

LETM with AQP4 positivity is NMOSD. MS DMTs (interferon, fingolimod) worsen NMOSD. Switch to rituximab, eculizumab, or satralizumab. A: Must change treatment. C: Natalizumab worsens NMOSD. D: Diagnosis changed. E: Delaying risks attacks.

Reference: ABN NMOSD Guidelines