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MS Fatigue – Validated Measurement Tools — SCE Neurology MCQ

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EasyMultiple Sclerosis & CNS InflammationMS Fatigue – Validated Measurement ToolsSCE Neurology

A 35-year-old woman with MS has significant fatigue that is not explained by depression, sleep disorder, or infection. She scores 55 on the Modified Fatigue Impact Scale (MFIS). Her neurologist wishes to characterise the fatigue systematically. What validated tool is specifically recommended for measuring MS-related fatigue?

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Correct answer: A — Modified Fatigue Impact Scale (MFIS) or Fatigue Severity Scale (FSS)

The Modified Fatigue Impact Scale (MFIS) and Fatigue Severity Scale (FSS) are the validated tools specifically recommended for measuring fatigue in MS. The MFIS assesses the impact of fatigue on physical, cognitive, and psychosocial functioning (21-item version scores 0–84). The FSS is a 9-item scale focusing on the severity and impact of fatigue. NICE NG100 recommends using validated fatigue measures. A: ESS measures sleepiness, not fatigue (they are distinct). C: HDRS measures depression. D: MMSE measures cognition. E: Barthel Index measures functional independence.

Reference: NICE NG100 MS (2022); Krupp et al. FSS