A 40-year-old with narcolepsy type 1 has persistent disabling daytime sleepiness and frequent cataplexy despite an adequate trial of modafinil. Which

Question

A 40-year-old with narcolepsy type 1 has persistent disabling daytime sleepiness and frequent cataplexy despite an adequate trial of modafinil. Which treatment is most likely to address both symptoms under specialist supervision?

Accepted Answer

Sodium oxybate at night with specialist monitoring of efficacy and safety

Answer

Clomipramine alone as treatment for daytime sleepiness and nocturnal sleep disruption

Answer

Continuous positive airway pressure without evidence of obstructive sleep apnoea syndrome

Answer

Methylphenidate alone as treatment for cataplexy and nocturnal sleep consolidation

Answer

Melatonin alone as treatment for cataplexy and excessive daytime sleepiness

Narcolepsy – Modafinil/Pitolisant for Sleepiness — SCE Neurology MCQ

A 40-year-old with narcolepsy type 1 has persistent disabling daytime sleepiness and frequent cataplexy despite an adequate trial of modafinil. Which treatment is most likely to address both symptoms under specialist supervision?