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PD – Non-Distressing Visual Hallucinations — SCE Neurology MCQ

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HardMovement DisordersPD – Non-Distressing Visual HallucinationsSCE Neurology

A 24-year-old with biochemically and genetically confirmed acute intermittent porphyria has had five attacks requiring hospital treatment in the past 11 months despite trigger management. Which statement best matches NICE access to givosiran?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — She meets the attack-frequency and age criteria for specialist consideration of givosiran

Explanation lettering: D = shown as C · E = shown as D · C = shown as E

A invents an age threshold and a requirement for chronic neuropathy. B is correct: NICE recommends givosiran as an option from age 12 for clinically confirmed severe recurrent acute hepatic porphyria defined by at least four attacks in 12 months, subject to the commercial arrangement and specialist service. C sets a much higher unsupported threshold. D confuses prophylaxis with acute rescue treatment, for which intravenous haem arginate may be used. E is below the recurrent-attack threshold.

Reference: NICE HST16: givosiran for acute hepatic porphyria: https://www.nice.org.uk/guidance/hst16/chapter/1-Recommendations