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Levetiracetam and Breastfeeding — SCE Neurology MCQ

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EasyEpilepsy & Seizure DisordersLevetiracetam and BreastfeedingSCE Neurology

A 28-year-old woman with well-controlled epilepsy on levetiracetam gives birth to a healthy baby. She wishes to breastfeed. What is the advice regarding levetiracetam and breastfeeding?

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Correct answer: D — Levetiracetam is present in breast milk at low concentrations and breastfeeding is generally considered safe

Levetiracetam is present in breast milk but at relatively low concentrations, and the amount received by the infant is generally considered unlikely to cause adverse effects. Current UK guidelines (including NICE NG217 and ABN guidance) support breastfeeding for women on levetiracetam, with monitoring of the infant for sedation or poor feeding. Lamotrigine is also generally compatible with breastfeeding. A: It is not absolutely contraindicated. C: Stopping risks seizures. D: Pump-and-dump is not required. E: Phenobarbital causes more infant sedation than levetiracetam.

Reference: NICE NG217 (2025); ABN Epilepsy and Pregnancy Guidelines