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ASM in Renal Impairment — SCE Neurology MCQ

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HardEpilepsy & Seizure DisordersASM in Renal ImpairmentSCE Neurology

A 62-kg adult remains in generalised convulsive status epilepticus after two adequate intravenous lorazepam doses. The team selects intravenous levetiracetam as second-line treatment. Which loading prescription is correct?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: ALevetiracetam 3,720 mg intravenously as the single second-line loading dose

Explanation lettering: E = shown as A · A = shown as E

A is a maintenance-style dose, not a status loading dose. B uses an outdated low loading calculation. C ignores weight below the maximum-dose threshold. D exceeds the recommended regimen. E is correct: 60 mg/kg × 62 kg = 3,720 mg, below the 4,500 mg cap. Ongoing airway, glucose, cause-specific management and escalation remain essential.

Reference: Epilepsy Society: Epilepsy notes: https://epilepsysociety.org.uk/sites/default/files/2023-10/Epilepsy_Notes_PDF_Book_2022_V6_0.pdf