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Anti-LGI1 – FBDS — SCE Neurology MCQ

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HardEpilepsy & Seizure DisordersAnti-LGI1 – FBDSSCE Neurology

A 34-year-old woman with anti-LGI1 encephalitis presents with confusion, seizures, and hyponatraemia. What is the characteristic seizure type?

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Correct answer: D — Faciobrachial dystonic seizures

FBDS are brief (<3 seconds), frequent, unilateral face and arm tonic posturing. Highly specific for anti-LGI1 antibodies. Hyponatraemia (SIADH) is characteristic. A: GTCS occur but are not the characteristic type. C: Gelastic seizures are hypothalamic hamartoma. D: Absence seizures are IGE. E: Infantile spasms are paediatric.

Reference: Irani et al. Brain (2011); ABN Autoimmune Encephalitis Guidelines