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CMT Type 2 — SCE Neurology MCQ

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ModeratePeripheral Neuropathy & NeuromuscularCMT Type 2SCE Neurology

A 48-year-old man with hereditary motor and sensory neuropathy has reduced CMAP amplitudes with normal conduction velocities, distal wasting, and pes cavus. His mother has similar feet. What type of CMT?

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Correct answer: D — CMT2 (axonal)

CMT2 is the axonal form with reduced CMAPs/SNAPs but normal velocities (≥38 m/s). CMT1 has uniformly slow velocities (<38 m/s). Most common CMT2 mutation is MFN2. A: CMT1 has slow velocities. C: HNPP has entrapment-site conduction block. D: CMT-X has intermediate velocities. E: HSAN has prominent autonomic features.

Reference: EAN/PNS CMT Guidelines