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Critical Illness Polyneuropathy — SCE Neurology MCQ

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ModeratePeripheral Neuropathy & NeuromuscularCritical Illness PolyneuropathySCE Neurology

A 60-year-old man after 3 weeks in ICU with septic shock has profound generalised weakness with areflexia. NCS show reduced CMAPs with normal sensory studies and normal velocities. What is the diagnosis?

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Correct answer: D — Critical illness polyneuropathy

CIP develops after prolonged ICU stays (sepsis, multi-organ failure). NCS show axonal motor > sensory neuropathy (reduced CMAPs, relatively preserved SNAPs). A: GBS typically develops before ICU admission. B: CIM shows myopathic EMG changes. D: Combined is common but pure CIP fits this NCS pattern. E: MG does not cause areflexia.

Reference: Bolton CF; EAN ICU-Acquired Weakness Guidelines