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RLS – Iron Deficiency — SCE Neurology MCQ

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EasySleep DisordersRLS – Iron DeficiencySCE Neurology

A 55-year-old man with an uncomfortable urge to move his legs, worse in the evening and at rest, relieved by movement. Ferritin is 8 µg/L. What is the first-line treatment?

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Correct answer: D — Iron supplementation

In RLS with iron deficiency (ferritin <75 µg/L), iron supplementation is first-line before dopaminergic therapy. Iron is essential for dopamine synthesis. A: Dopamine agonists are first-line only after iron is replete. C: Gabapentin is an alternative but iron must be addressed first. D: Clonazepam is not first-line. E: Levodopa causes augmentation.

Reference: EAN/IRLSSG RLS Guidelines (2016)