VHL – Haemangioblastoma — SCE Neurology MCQ

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ModerateNeuro-oncologyVHL – HaemangioblastomaSCE Neurology

A 45-year-old man with VHL disease has a cystic cerebellar lesion with enhancing mural nodule on MRI. He has episodic headaches and sweating. What is the cerebellar pathology?

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Correct answer: B — Haemangioblastoma

Haemangioblastomas are the characteristic CNS tumour of VHL (VHL gene mutation). They present as cystic lesions with enhancing mural nodules in the posterior fossa. VHL also includes RCC, phaeochromocytoma, and retinal angiomas. A: Pilocytic astrocytoma looks similar but is not VHL-associated. C/D: Different imaging features. E: Abscess has rim enhancement with DWI restriction.

Reference: NICE NG99; VHL Diagnostic Criteria