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Oligodendroglioma – 1p/19q — SCE Neurology MCQ

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ModerateNeuro-oncologyOligodendroglioma – 1p/19qSCE Neurology

A 55-year-old woman with oligodendroglioma WHO grade 3 has 1p/19q co-deletion and IDH1 mutation. What is the prognostic significance of 1p/19q co-deletion?

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Correct answer: D — Better prognosis and predicts response to PCV chemotherapy

1p/19q co-deletion defines oligodendrogliomas (WHO 2021) and predicts better prognosis and PCV chemotherapy response. IDH mutation further improves prognosis. A: It confers better prognosis. C: GBMs are IDH-wildtype. D: It is a strong marker. E: It is a primary brain tumour marker.

Reference: WHO CNS Classification (2021); NICE NG99