Uhthoff Phenomenon — SCE Neurology MCQ

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EasyMultiple Sclerosis & CNS InflammationUhthoff PhenomenonSCE Neurology

A 35-year-old woman with RRMS notices worsening blurred vision and leg weakness after a hot bath. Symptoms resolve within 30 minutes of cooling. No new MRI lesions. What is this phenomenon?

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Correct answer: B — Uhthoff phenomenon

Uhthoff phenomenon is transient worsening of MS symptoms due to increased body temperature. Heat slows conduction in demyelinated axons. It is not a relapse and requires no treatment beyond cooling. A: A relapse requires new symptoms lasting >24 hours. C: Lhermitte sign is electric shock on neck flexion. D: Paroxysmal symptoms are brief stereotyped events. E: Pseudoexacerbation is a broader term.

Reference: NICE NG100 MS (2022)