skip to main content

PD – Apomorphine Infusion Indication — SCE Neurology MCQ

Instant feedback + full explanation. One question, done properly.

ModerateMovement DisordersPD – Apomorphine Infusion IndicationSCE Neurology

A 70-year-old man with Parkinson's disease has been referred for consideration of apomorphine. When is subcutaneous apomorphine infusion indicated?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — For patients with severe motor fluctuations not adequately controlled by optimised oral/transdermal therapy

Subcutaneous apomorphine infusion is indicated for patients with advanced PD with severe, unpredictable motor fluctuations (off periods) not adequately controlled by optimised oral and/or transdermal dopaminergic therapy. NICE NG71 recommends considering apomorphine infusion or LCIG for patients whose motor fluctuations are not adequately managed by oral therapy. Apomorphine is a potent D1/D2 dopamine agonist. A: It is not first-line. C: Cognitive impairment is not a specific indication for apomorphine. D: It is an alternative to DBS, not a post-DBS option only. E: Apomorphine challenge tests can support diagnosis but continuous infusion is for treatment.

Reference: NICE NG71 Parkinson's Disease (2017)