skip to main content

MS – Fampridine for Walking — SCE Neurology MCQ

Instant feedback + full explanation. One question, done properly.

HardMultiple Sclerosis & CNS InflammationMS – Fampridine for WalkingSCE Neurology

A 30-year-old with episodic weakness has a small mandible, low-set ears, clinodactyly and frequent ventricular ectopy. Genetic testing confirms KCNJ2-related Andersen-Tawil syndrome. Weakness attacks are rare and a long-exercise test is normal. Which surveillance remains essential?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Annual cardiology review with extended ECG monitoring

Explanation lettering: B = shown as A · D = shown as B · A = shown as D

C is correct: Andersen-Tawil syndrome combines periodic paralysis, dysmorphic features and ventricular arrhythmia; all affected patients require regular cardiology review and extended ECG monitoring even when symptoms are minimal. A normal long-exercise test does not exclude the diagnosis and serial repetition is not the safety priority. CK does not monitor arrhythmic risk. Waiting for palpitations is unsafe because clinically important ventricular arrhythmia may be asymptomatic.

Reference: Skeletal muscle channelopathies: a guide to diagnosis and management: https://pn.bmj.com/content/21/3/196